What is the use of fenfluramine?

Fenfluramine is used to help control seizures in people with Dravet syndrome.

Is fenfluramine used as appetite suppressant?

Fenfluramine was an appetite suppressant which was used to treat obesity. It was used both on its own and, in combination with phentermine, as part of the anti-obesity medication Fen-Phen. In June 2020, fenfluramine was approved for medical use in the United States with an indication to treat Dravet syndrome.

Can phentermine cause heart damage?

Serious heart valve problems or disease have been reported in patients taking phentermine or other phentermine-like products for weight loss.

What happens after you stop taking phentermine?

If you suddenly stop using this medication, you may have withdrawal symptoms (such as depression, severe tiredness). To help prevent withdrawal, your doctor may lower your dose slowly. Withdrawal is more likely if you have used phentermine for a long time or in high doses.

What are the dangers of phentermine?

Common side effects of phentermine include:

• Increased heart rate.
• Tingling or prickling feeling in hands or feet.
• Dry mouth.
• Sleeplessness.
• Nervousness.
• Constipation.

Is phentermine safe to take?

Phentermine alone, however, has been used for decades and appears to be a safe and effective weight loss medication when used in the short-term in healthy individuals. One study found that phentermine significantly reduced weight without raising blood pressure or causing other heart problems.

What is the mechanism of action of aminorex and fenfluramine?

Both aminorex and fenfluramine are serotonin transporter substrates and act by increasing extracellular (5-HT). 5-HT, in turn, causes vasoconstriction and pulmonary vascular remodeling through induction of proliferation of both pulmonary arterial fibroblasts and pulmonary arterial SMCs.

What is another name for fenfluramine?

Fenfluramine is a substituted amphetamine and is also known as 3-trifluoromethyl-N-ethylamphetamine. It is a racemic mixture of two enantiomers, dexfenfluramine and levofenfluramine. Some analogues of fenfluramine include norfenfluramine, benfluorex, flucetorex, and fludorex .

What is aminorex?

Aminorex. Aminorex ( Menocil, Apiquel, aminoxaphen, aminoxafen, McN-742) is a weight loss ( anorectic) stimulant drug. It was withdrawn from the market after it was found to cause pulmonary hypertension. In the U.S., it is an illegal Schedule I drug, meaning it has high abuse potential, no accepted medical use, and a poor safety profile.

What are the long-term effects of fenfluramine treatment?

There have been reports associating chronic fenfluramine treatment with emotional instability, cognitive deficits, depression, psychosis, exacerbation of pre-existing psychosis ( schizophrenia ), and sleep disturbances.