What does low Alpha-2 globulin mean?
Decreased alpha-2 globulin proteins may indicate: Breakdown of red blood cells (hemolysis)
What causes decreased alpha-1 globulin?
Levels of α-1-AT below 30% of normal values indicate a risk of damage caused by the activation of the digesting enzymes (early pulmonary emphysema or liver cirrhosis). Low levels can also be observed in situations that lead to a general decline in serum proteins such as kidney disease, malnutrition and certain cancers.
What does low level of globulin mean?
Your liver makes globulin, a protein. High levels may indicate autoimmune disease, infections or cancer. A low globulin reading may be a sign of liver or kidney disease. A globulin test may be part of liver function tests or a metabolic panel.
What is Alpha 2 in blood test?
Alpha-2 globulins: This class of protein has many functions in the body and is involved in inflammation. Beta globulins: These proteins move substances, support immunity, and increase in number in multiple myeloma and conditions like high cholesterol and atherosclerosis.
What does it mean to have low globulin?
Low globulin levels may be a sign of liver or kidney disease, or malnutrition. High globulin levels may be a sign of: Infection. Inflammatory disease. Immune disorders.
What is the clinical significance of alpha-2 macroglobulin?
Clinical Information Alpha-2-macroglobulin is a protease inhibitor and is one of the largest plasma proteins. It transports hormones and enzymes, exhibits effector and inhibitor functions in the development of the lymphatic system, and inhibits components of the complement system and hemostasis system.
Why does alpha 2 globulin increase in nephrotic syndrome?
α2-Macroglobulin levels are increased when the serum albumin levels are low, which is most commonly seen in nephrotic syndrome, a condition wherein the kidneys start to leak out some of the smaller blood proteins. Because of its size, α2-macroglobulin is retained in the bloodstream.
When should I be concerned about low globulin levels?
What are alpha-2 globulins?
Alpha-2 globulins is a class of proteins that has many functions in the body and is involved in inflammation. Proteins are substances made of small chemicals called amino acids. They have a number of roles: – They provide structure to the body.
What does it mean when your alpha-2-globulin and gamma globulin levels increase?
In general, alpha and gamma globulin protein levels increase when there is inflammation in the body. What does it mean if your Alpha-2-Globulin, Serum result is too low? What does it mean if your Alpha-2-Globulin, Serum result is too high?
What does it mean if your alpha-2-globulin serum result is too low?
In general, alpha and gamma globulin protein levels increase when there is inflammation in the body. What does it mean if your Alpha-2-Globulin, Serum result is too low? Decreased alpha-2 globulin proteins may indicate: Breakdown of red blood cells
What is alpha-2-macroglobulin?
α2-Macroglobulin ( α2M ), or alpha-2-macroglobulin, is a large (720 KDa) plasma protein found in the blood. It is mainly produced by the liver, and also locally synthesized by macrophages, fibroblasts, and adrenocortical cells.