What is SPP1 gene?

SPP1 (Secreted Phosphoprotein 1) is a Protein Coding gene. Diseases associated with SPP1 include Pediatric Systemic Lupus Erythematosus and Nephrolithiasis, Calcium Oxalate. Among its related pathways are Metabolism of proteins and Integrins in angiogenesis.

What is the role of the osteopontin?

Osteopontin (OPN) is a versatile protein that acts on various receptors which are associated with different signalling pathways implicated in cancer. OPN mediates critical processes for cancer progression such as immune response, cell adhesion and migration, and tumorigenesis.

Where is osteopontin expressed?

Osteopontin (OPN) is expressed in a range of immune cells, including macrophages, neutrophils, dendritic cells, microglia and T and B cells, with varying kinetics.

What is osteopontin and osteocalcin?

Osteocalcin (OC) and osteopontin (OPN) are major non-collagenous proteins (NCPs) involved in bone matrix organization and deposition. In spite of this, it is currently unknown whether OC and OPN alter bone morphology and consequently affect bone fracture resistance.

What is the osteopontin gene?

Osteopontin is an extracellular structural protein and therefore an organic component of bone. Synonyms for this protein include sialoprotein I and 44K BPP (bone phosphoprotein). The gene has 7 exons, spans 5 kilobases in length and in humans it is located on the long arm of chromosome 4 region 22 (4q1322.1).

How is osteopontin produced in macrophages?

“Osteopontin is produced by rat cardiac fibroblasts and mediates A (II)-induced DNA synthesis and collagen gel contraction”. J. Clin. Invest. 98 (10): 2218–27. doi: 10.1172/JCI119031. PMC 507670. PMID 8941637. ^ Murry CE, Giachelli CM, Schwartz SM, Vracko R (December 1994). “Macrophages express osteopontin during repair of myocardial necrosis”. Am.

What is the role of osteopontin in the pathophysiology of fibrosis?

^ Vetrone SA, Montecino-Rodriguez E, Kudryashova E, Kramerova I, Hoffman EP, Liu SD, Miceli MC, Spencer MJ (2009). “Osteopontin promotes fibrosis in dystrophic mouse muscle by modulating immune cell subsets and intramuscular TGF-beta”.

What is osteopontin and how does it affect mast cells?

“Osteopontin is produced by mast cells and affects IgE-mediated degranulation and migration of mast cells”. Eur. J. Immunol. 38 (2): 489–99. doi: 10.1002/eji.200737057. PMID 18200503. ^ Burdo TH, Wood MR, Fox HS (June 2007). “Osteopontin prevents monocyte recirculation and apoptosis”. J. Leukoc. Biol. 81 (6): 1504–11. doi: 10.1189/jlb.1106711.