What is normal SUV uptake on a PET scan?

What is normal SUV uptake on a PET scan?

Typically, a standardized uptake value (SUV), a quantity that incorporates the patient’s size and the injected dose, that is more than 2.0 is considered to be suggestive of malignancy, whereas lesions with SUVs less than this value are considered to be benign. The SUV of this nodule in the right upper lobe is 4.0.

What is considered a high SUV on a PET scan?

The highest SUV in a transformed lymphoma PET scan (SUV(study-max)) ranged from 3.2 to 40, mean 15, median 12. Twenty-five of 40 patients (63%) presented with an SUV(study-max)>10 and 20 (50%)>13.

What does increased uptake mean on a bone scan?

Increased uptake of the radioisotope is called a hot spot, which indicates an abnormality. Bone scans are very sensitive for malignancies, and often used for evaluation of tumors that are likely to metastasize to the bones (see Fig. 6.15). An abnormal bone scan suggesting widespread metastasis from prostate cancer.

How accurate are bone scans?

Results: The sensitivity, specificity, and accuracy for detecting skeletal metastatic disease of FDG PET/CT were 97%, 98%, and 98%, respectively, and of bone scan were 83%, 98%, and 93%, respectively. The lesions that bone scan most commonly missed were located in the pelvis, spine, and sacrum.

What is normal bone SUV?

In a study of 47 bone tumors, Shin et al. reported a threshold SUV value of 3.7 [26], while Duarte et al determined the SUVmax threshold for differentiation between malignant and benign bone lesions to be 2.5 [27]. Kurdziel et al reported that normal bone should have SUV of 10 or less on NaF18 PET/CT [5].

What is standard uptake value in PET?

Standardized uptake value (SUV) is a semiquantitative measurement of uptake in tissue. Many factors affect the SUV, including accuracy of dose calibration, time between injection and imaging (dose to scan time), patient weight (changes are common in oncology patients), motion artifacts, and blood glucose levels.

Is FDG uptake adequate for characterizing primary bone tumors?

CONCLUSION. FDG uptake alone is not adequate for characterizing primary bone tumors, and morphologic evaluation is an important factor in the interpretation of PET/CT scans. After diagnosis, FDG avidity and morphologic features can play an important role in staging and determining response to therapy.

Is bone marrow high in FDG?

In some patients undergoing FDG-PET/CT for detecting the focus of infection, markedly increased FDG uptake is seen in the bone marrow or spleen. The bone marrow and spleen are generally regarded as “hypermetabolic” when their FDG avidity exceeds that of the liver (bone marrow/liver ratio or spleen/liver ratio > 1.0) [8].

What is the normal range of FDG uptake?

The median BLR was 0.76 (IQR 0.40), and 38 patients (26%) showed increased FDG uptake in the bone marrow (BLR > 1.00). The median SLR was 1.01 (IQR 0.31), with 75 patients (52%) showing increased FDG uptake in the spleen (SLR > 1.00).

What is the FDG uptake for fibrous dysplasia?

C, Different tumors of same histologic type do not always show consistent degree of FDG uptake. Maximum standardized uptake value of this lesion is 2.9. Note higher FDG uptake in equally nonaggressive fibrous dysplasia in Figure 7.