Is PVNS cancerous?

Pigmented villonodular synovitis (PVNS) is a type of benign (non-cancerous) tumor that arises from the soft connective tissue of joints. Any joint can be affected, although the tumor is most commonly found in the knee or hip joint. Although it can be painful, PVNS usually does not spread.

What is pigmented villonodular synovitis?

Pigmented villonodular synovitis (PVNS) is a condition that causes the synovium—the thin layer of tissue that lines the joints and tendons—to thicken and overgrow. The mass or tumor that results from this overgrowth is not cancerous and does not spread (metastasize) to other areas of the body.

What are the symptoms of PVNS?

What are the signs and symptoms of PVNS?

• swelling of a joint.
• joint effusion in the joint, which is a build-up of fluid which is usually bloody.
• aches and pain in the area affected.
• some people start limping and find it difficult to use the limb affected if the problem is with the leg, arm, hand or foot.

Is PVNS fatal?

PVNS has been described as a growth or a tumor in the lining of the joint. While it is accurately labeled as a tumor, it is not cancer and it is not typically life-threatening.

What is the histopathologic diagnosis of pigmented villonodular synovitis?

The histopathologic diagnosis was pigmented villonodular synovitis. Review of the cytologic smears revealed clusters of round and ovoid, bland-looking cells along with siderophages and binucleated and multinucleated giant cells.

What is the treatment for pigmented villonodular synovitis (PVNS)?

Pigmented villonodular synovitis (PVNS) is a rare condition resulting from hyperproliferation and fibrosis of the synovial lining. Surgical synovectomy is used to remove the hyperplastic tissue, but effectiveness is limited by regrowth. Moreover, surgical synovectomy is not effective in the diffuse form of PVNS.

What is the histologic appearance of polymyositis with nodular synovium (PVNS)?

Malignant transformation of PVNS is rare, and controversy exists as to histologic criteria for its diagnosis. Macroscopic appearance Macroscopically the synovium is diffusely thickened with multiple villous and nodular projections.

What is diffuse villonodular synovitis?

The diffuse type, also known as pigmented villonodular synovitis (PVNS), is a locally destructive lesion with an infiltrative growth pattern, occurring at intra- and extra-articular sites. The diffuse lesion tends to affect younger patients than its localized counterpart.