Which is antihemophilic factor?
Antihemophilic factor (AHF) is a protein that is produced naturally in the body. It helps the blood form clots to stop bleeding and prevents bleeding problems from happening as often. Hemophilia A, also called classical hemophilia, is a condition where the body does not make enough AHF.
Is ADVATE a factor 8?
What is ADVATE? ADVATE is a plasma/albumin-free recombinant factor VIII replacement therapy for patients with hemophilia A. ADVATE is indicated for prophylaxis, on-demand, and perioperative use in children and adults with hemophilia A and has an established safety profile.
How do you get antihemophilic factors?
A doctor or other trained health professional will give you or your child this medicine in a hospital or clinic setting. This medicine is given through a needle placed in one of your veins.
Who makes Eloctate?
Manufacturer: Biogen Idec, Inc.
How is Eloctate made?
Eloctate is the first recombinant clotting factor VIII therapy designed to stay in the body for a considerable period. Its namesake company used Fc fusion technology to develop it. This involves fusing factor VIII to what is called the Fc portion of a protein known as immunoglobulin G subclass 1, or IgG1.
How do you administer Eloctate?
Perform intravenous bolus infusion. The rate of administration should be determined by the patient’s comfort level, and no faster than 10 ml per minute. After infusing ELOCTATE, remove and properly discard the infusion set.
When was Eloctate FDA approved?
On Friday, June 6, 2014, the U.S. Food and Drug Administration approved Eloctate, Antihemophilic Factor (Recombinant), Fc fusion protein, for use in adults and children who have hemophilia A.
What is Fletcher factor?
Prekallikrein (PK), also known as Fletcher factor, is an 85,000 Mr serine protease that complexes with high-molecular-weight kininogen. PK is the precursor of plasma kallikrein, which is a serine protease that activates kinins. PK is cleaved to produce kallikrein by activated Factor XII (Hageman factor).
How long does Antihemophilic Factor last?
Control And Prevention Of Bleeding Episodes Repeat infusions every 12 to 24 hours (8 to 24 hours for patients under the age of 6) for one to three days until the bleeding episode is resolved (as indicated by relief of pain) or healing is achieved.
Is Eloctate a biologic?
WESTON, Mass. –(BUSINESS WIRE)–Biogen Idec (NASDAQ: BIIB) announced today that the U.S. Food and Drug Administration (FDA) has accepted the company’s Biologics License Application (BLA) for the marketing approval of ELOCTATE™ (recombinant factor VIII Fc fusion protein) for the treatment of hemophilia A.
What activates Hageman factor?
Abstract. The activation and function of surface-bound Hageman factor in human plasma are dependent upon both high molecular weight (HMW) kininogen and prekallikrein.
What is the cost of antihemophilic factor?
For example, the average retail price per prescription of Advate â€“ a third-generation recombinant antihemophilic factor for hemophilia A with a standard half-life of 12 to 14 hours that was first FDA approved in 2003 â€“ is $20,630.