What is the mechanism of action of anidulafungin?

What is the mechanism of action of anidulafungin?

Mechanism of action Anidulafungin inhibits glucan synthase, an enzyme important in the formation of (1→3)-β-D-glucan, a major fungal cell wall component. Glucan synthase is not present in mammalian cells, so it is an attractive target for antifungal activity.

What is anidulafungin used for?

It is used to treat fungal infections including candidemia (fungal infection in the blood), candida peritonitis and abscess (fungal infection in the stomach), esophageal candidiasis (fungal infection in the esophagus), and other fungal infections (including infections in the stomach).

What class of drug is anidulafungin?

Anidulafungin belongs to a class of drugs known as echinocandins. It works by stopping the growth of fungi.

How do you administer eraxis?

The recommended dose is a single 100 mg loading dose of ERAXIS on Day 1, followed by a 50 mg once daily maintenance dose thereafter. Patients should be treated for a minimum of 14 days and for at least 7 days following resolution of symptoms. Duration of treatment should be based on the patient’s clinical response.

What are side effects of itraconazole?

Side Effects

  • Decreased urine output.
  • increased thirst.
  • irregular heartbeat.
  • mood changes.
  • muscle pain or cramps.
  • numbness or tingling in the hands, feet, or lips.
  • trouble breathing.

What does eraxis treat?

Anidulafungin is an antifungal medicine that is used to treat candida (yeast) infections in the blood or the stomach in adults and children at least 1 month old. Anidulafungin is also used to treat candida infections of the esophagus only in adults.

What is anidulafungin?

Anidulafungin is a semisynthetic lipopeptide synthesized from fermentation products of Aspergillus nidulans.

Can anidulafungin pass through the blood-brain barrier?

Anidulafungin is extensively bound (>99 %) to human plasma proteins. No specific tissue distribution studies of anidulafungin have been done in humans. Therefore, no information is available about the penetration of anidulafungin into the cerebrospinal fluid (CSF) and/or across the blood-brain barrier.

Is anidulafungin effective for refractory mucosal candidiasis?

Azole-refractory mucosal candidiasis. Anidulafungin is also effective in treating patients with fluconazole-refractory mucosal candidiasis. Anidulafungin was evaluated in a small, open-label clinical trial in patients with refractory OPC or EC whose treatment of at least 14 days of fluconazole treatment (>200 mg daily) had failed.

How effective is anidulafungin in the treatment of neutropenic patients?

The efficacy of anidulafungin (200 mg intravenous loading dose followed by 100 mg intravenous daily) was assessed in 35 adult neutropenic patients defined as absolute neutrophil count ≤ 500 cells/mm 3 or WBC ≤ 500 cells/mm 3 in 22 patients or classified by the investigator as neutropenic at baseline in 13 patients.