What is ifosfamide used for?

Ifosfamide is a chemotherapy drug used to treat many different types of cancer.

What type of drug is ifosfamide?

Ifosfamide is in a class of medications called alkylating agents. It works by slowing or stopping the growth of cancer cells in your body.

What cancer does ifosfamide treat?

Ifosfamide is a cytotoxic, antineoplastic drug used to manage and treat various cancers such as lymphoma, sarcoma, and lung cancer.

How long does ifosfamide stay in your system?

Empty your bladder often during the day and night. If you have problems drinking, have any pain, or see blood in your urine, tell your cancer care team soon as possible. This may happen 7 to 14 days after the drug is given. After that, your blood counts should return to normal.

Can ifosfamide cause seizures?

These metabolites are excreted predominantly by the kidneys [2]. Neurotoxicity can manifest in several ways, including lethargy, agitation, disorientation, confusion, hallucinations, extra-pyramidal signs and seizures [1, 5]. In rare cases, the symptoms can progress to coma, irreversible brain damage and death [1].

What is ifosfamide toxicity?

Central nervous system (CNS) toxicity has been reported in approximately 10%–30% of patients receiving intravenous infusions of ifosfamide. Encephalopathy is a rare but serious CNS adverse reaction in these patients, and although usually transient and reversible, may cause persistent neurological dysfunction or death.

How do you give ifosfamide?

Ifosfamide is give through an infusion into a vein (intravenous, IV). The amount of ifosfamide that you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer or condition being treated.

How is ifosfamide toxicity treated?

The recommended dose of intravenous MB for treatment of ifosfamide-induced encephalopathy is 50 mg every 4 hours (1% aqueous solution over 5 minutes), whereas the dose for secondary prophylaxis of ifosfamide-induced encephalopathy is 50 mg every 6 hours, either intravenously or orally [8].

What should I know about ifosfamide before taking it?

Ifosfamide affects your immune system. You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, chills, cough, mouth sores, or unusual bleeding or bruising. Ifosfamide can affect your kidneys or nervous system.

What is the rate of incidence for ifosfamide toxicity?

It occurs in some form in up to 50% of people receiving the agent. The reaction is probably mediated by chloroacetaldehyde, one of the breakdown products of the ifosfamide molecule, which has chemical properties similar to acetaldehyde and chloral hydrate.

What are the possible side effects of ifosfamide and mesna?

Hemorrhagic cystitis is rare when ifosfamide is given with mesna. A common and dose-limiting side effect is encephalopathy (brain dysfunction). It occurs in some form in up to 50% of people receiving the agent.

What are the treatment options for acidosis caused by ifosfamide?

Other treatments include albumin and thiamine, and dialysis as a rescue modality. Ifosfamide may also cause a normal anion gap acidosis, specifically renal tubular acidosis type 2. ^ a b c d e f g h i “Ifosfamide”.